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Low substituted hydroxypropy cellulose (L-HPC)
    Time:2017-11-16 13:48:09    Hits:831
Low substituted hydroxypropy cellulose (L-HPC) CAS NO.: 9004-64-2
SHANDONG MEDICAL PRODUCTION LICENSE NO. F2014062
Packing specifications: 20 kg/bag 20 kg/bucket
Quality standard: CP2015, USP current edition
Main application:
The product is low-substituted hydroxy propyl cellulose, a kind of multipurpose non-ionic cellulose derivative, mainly used as disintegrant and adhesive of solid preparation, and due to large surface area and porosity of its powder, it can quickly absorb water to expand and increase the swelling property. When used for tablet, it can make the tablet quickly disintegrate, and its coarse structure makes it have large mosaicism with drugs and particles, which can obviously improve hardness and glossiness of the tablet. For the drug difficult to mold, it can improve compactibility, fragility and decentralization to enhance hardness of the tablet and accelerate disintegration of the tablet. Further accelerate dissolution rate of the drug and improve bioavailability. Dosage of the product generally is 2%-5%, and in the tablet production, it can be used for wet granulation, and can be internally or externally added into particle tabletting. It can also be used in rapid disintegration tablet of direct compression preparation.
Leading indicator Standard CP2015 Standard USP
PH 5.0-7.5 5.0-7.5
Loss on drying ≤8.0% ≤5.0%
Residue on ignition ≤1.0% ≤0.5%
Heavy metal ≤0.0002% ≤0.0001%
Content 5.0-16.0 5.0-16.0

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